Intracellular Pattern Formation: A Spatial Stochastic Model of Bacterial division site selection proteins MinCDE
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چکیده
Bacterial division site selection is regulated by members of the Min-protein system. In Escherichia coli MinC, MinD, and MinE oscillate from pole to pole of the cell with a periodicity of approximately 40 sec. The region of lowest concentration of the Z-Ring inhibitor, MinC occurs at the center of the cell, confining the placement of FtsZ and thus defining the cell division site. In addition to its oscillatory behavior, it has been shown that MinD forms filamentous structures in vivo and in vitro. The mechanism for this phenomena remains unclear. We show that filament formation can be explained by a model based on in vitro-observed interactions.
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تاریخ انتشار 2004